王逸平-中国科学院大学-UCAS
[中文]
[English]
教育背景
工作经历
专利与奖励
出版信息
科研活动
基本信息
王逸平 男 博导 中国科学院上海药物研究所电子邮件： ypwang@mail.shcnc.ac.cn通信地址： 上海张江祖冲之路555号邮政编码： 201203
招生信息
招生专业
100706-药理学
招生方向
心血管药理学
教育背景
1995-09--2001-06 中科院上海药物研究所 理学博士1985-09--1988-07 上海第二医科大学 药理学硕士1980-09--1985-07 上海第二医科大学 医学学士
工作经历
工作简历
2002-02~现在, 中科院上海药物研究所, 课题组长/研究员1995-09~2001-06,中科院上海药物研究所, 理学博士1994-04~现在, 中科院上海药物研究所, 课题组长1993-11~现在, 中科院上海药物研究所, 副研究员1990-11~现在, 中科院上海药物研究所, 助理研究员1988-08~现在, 中科院上海药物研究所, 研究实习员1985-09~1988-07,上海第二医科大学, 药理学硕士1980-09~1985-07,上海第二医科大学, 医学学士
专利与奖励
奖励信息
（1）&nbsp丹参多酚酸盐项目研究集体,&nbsp部委级,&nbsp2013（2）&nbsp丹参多酚酸盐及其粉针剂,&nbsp二等奖,&nbsp国家级,&nbsp2011（3）&nbsp丹参多酚酸盐及其粉针剂,&nbsp一等奖,&nbsp省级,&nbsp2007
专利成果
（ 1 ）&nbsp唑类杂环化合物、其制备方法、药物组合物及用途,&nbsp2013,&nbsp第 2 作者,&nbsp专利号: PCT，WO2013000267（ 2 ）&nbspN－取代苄基或苯芳香磺酰胺化合物及其用途,&nbsp2004,&nbsp第 4 作者,&nbsp专利号: ZL99124236.X（ 3 ）&nbsp丹参多酚酸盐的制备方法和用途,&nbsp2003,&nbsp第 3 作者,&nbsp专利号: ZL 98111076.2（ 4 ）&nbsp3.N-Substituted Benzyl or Phenyl Aromatic Sulfonamide Compounds and Use thereof,&nbsp2003,&nbsp第 4 作者,&nbsp专利号: US 6,605,635 B1
出版信息
发表论文
（1） Structural and thermodynamic characterization of protein-ligand interactions formed between lipoprotein-associated phospholipase A2 and inhibition, J Med Chem, 2016, 通讯作者（2） Discovery of a Novel Series of Imidazo[1,2-a]pyrimidine erivatives as Potent and Orally Bioavailable Lipoprotein-Associated Phospholipase A2 Inhibitors, J Med Chem, 2015, 通讯作者（3） Sodium Tanshinone IIA silate inhibits high glucose-induced vascular smooth muscle cell proliferation and migration through activation of AMP-activated protein kinase, PLos ONE, 2014, 通讯作者（4） MG132, a proteasome inhibitor, enhances LDL uptake in HepG2 cells in vitro by regulating LDLR and PCSK9 expression, Acta Pharmacol Sin, 2014, 通讯作者（5） Lancolides, Antiplatelet Aggregation Nortriterpenoids with Tricyclo[6.3.0.02,11]undecane-Bridged System from Schisandra lancifolia, ORGANIC LETTERS, 2013, 通讯作者（6） A series of Darapladib analogues as orally active Lp-PLA2 inhibitors, Bioorganic & Medicinal Chemistry Letters, 2013, 通讯作者（7） Design and synthesis of imidazole and triazole derivatives as Lp-PLA2 inhibitors and the unexpected discovery of highly potent quaternary ammonium salts, Bioorganic & Medicinal Chemistry Letters, 2013, 通讯作者（8） Akt mediates sodium tanshinone IIA silate inhibition of oxygen-glucose deprivation/reperfusion-induced myocardial cell apoptosis via suppression of the NF-κB/TNF-α pathway, Br J Pharmacol, 2013, 通讯作者（9） Hyperlipidemia and Atherosclerotic Lesion Development in Ldlr-deficient Mice on a Long-Term High-fat Diet, PLos ONE, 2012, 通讯作者（10） Pharmacological actions and therapeutic applications of Salvia miltiorrhiza depside salt and its active components, Acta Pharmacol Sin, 2012, 通讯作者（11） Discovery of N-(3,5-bis(1-pyrrolidylmethyl)-4-hydroxybenzyl)-4- methoxybenzenesulfamide (sulcardine) as a novel anti-arrhythmic agent, Acta Pharmacol Sin, 2012, 通讯作者（12） Contribution of Carboxylesterase in Hamster to the Intestinal First-Pass Loss and Low Bioavailability of Ethyl Piperate, an Effective Lipid-Lowering Drug Candidate, Drug Metabolism and Disposition, 2011, 通讯作者（13） Inhibition of Lipoprotein-Associated Phospholipase A2 Ameliorates Inflammation and Decreases Atherosclerotic Plaque Formation in ApoE-Deficient Mice, PLos ONE, 2011, 通讯作者（14） Magnesium lithospermate B decreases [Ca2+]i in endothelial cells by inhibiting K+ currents, Eur J Pharmacol 650: 285–289, 2011, 通讯作者（15） Magnesium lithospermate B dilates mesenteric arteries by activating BKCa currents and contracts arteries by inhibiting KV currents, Acta Pharmacol Sin 31: 665–670, 2010, 通讯作者（16） OxLDL stimulates lipoprotein-associated phospholipase A2 expression in THP-1 monocytes via PI3K and p38 MAPK pathways, Cardiovasc Res 85(4):845-52, 2010, 通讯作者（17） Cellular electrophysiological effects of changrolin in isolated rat cardiac myocytes, Eur J Pharmacol 647:139-146, 2010, 通讯作者（18） Effects of Magnesium Lithospermate B and its Analogues on Ca2+ Homeostasis in Cultured Rat Thoracic Aorta Vascular Smooth Muscle Cells, Planta Med 75: 1573–1579, 2009, 通讯作者（19） Liquid chromatography/tandem mass spectrometry for the determination of changrolin in rat plasma: application to a bioavailability study, Journal of Pharmaceutical and Biomedical Analysis 50: 189–193, 2009, 通讯作者
科研活动
科研项目
（ 1 ）&nbsp上海市新药临床前药效学与安全性评价专业技术服务平台, 负责人, 地方任务, 2015-07--2017-07
2013 中国科学院大学，网络信息中心.